October 18, 2024 - 🧬 [nGram] Your Weekly Business Development Insights (11th Oct 24 - 17th Oct 24): Merck's RSV Win, Pfizer's $1.5B Deal, FDA Approvals


  1. Alzamend Neuro's AL001 shows promising safety and efficacy in Phase IIA trial for Alzheimer's Disease, advancing lithium therapy without traditional monitoring.
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  2. BioVersys completes Phase 2 trial of BV100 for Ventilator-Associated Bacterial Pneumonia, showing safety and efficacy against Carbapenem-Resistant Acinetobacter baumannii.
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  3. Akeso's Phase 3 trial shows cadonilimab significantly improves progression-free and overall survival in Cervical Cancer, published in The Lancet.
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  4. Marinus Pharmaceuticals' Phase 3 RAISE trial shows IV ganaxolone rapidly ceases Status Epilepticus in refractory patients, meeting one co-primary endpoint.
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  5. ViiV Healthcare's Apretude (cabotegravir long-acting) shows over 99% effectiveness in real-world studies for HIV pre-exposure prophylaxis, reducing stigma and anxiety, as presented at IDWeek 2024.
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  6. Merck's clesrovimab shows promise in reducing RSV-related infections and hospitalizations in infants, challenging Sanofi and AstraZeneca's Beyfortus.
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  7. Factor Bioscience and Eterna Therapeutics partner to advance cell therapies for Oncology, Autoimmune, and Rare Diseases using iPSC technology.
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  8. Pfizer partners with Triana Biomedicines in a $1.5B deal to develop molecular glue degraders for cancer and other diseases.
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  9. Sanofi and Orano Med partner to develop radioligand therapies for rare cancers using lead-212 isotopes.
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  10. Tonix Pharmaceuticals receives initial payment from U.S. Department of Defense for developing broad-spectrum antivirals under a $34 million contract.
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  11. FDA approves VYALEVâ„¢ for continuous subcutaneous infusion to manage motor fluctuations in advanced Parkinson's Disease.
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  12. Valneva and LimmaTech's tetravalent Shigella vaccine candidate receives FDA Fast Track designation to expedite development for Shigellosis prevention.
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  13. Novocure's Tumor Treating Fields receives FDA approval for metastatic non-small cell lung cancer, marking a significant survival improvement.
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  14. New genomic study identifies unique mutations in Black patients with Acute Myeloid Leukemia, challenging existing risk frameworks.
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  15. Avacta introduces AVA6103 and AVA7100, novel pre|CISION®-enabled oncology assets, enhancing targeted cancer treatment with reduced systemic toxicity.
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  16. Cullinan Therapeutics' CLN-978 receives FDA IND clearance for Phase 1 trial in Systemic Lupus Erythematosus.
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  17. Latigo Biotherapeutics initiates Phase 1 trial of LTG-305, a non-opioid Nav1.8 inhibitor, for chronic pain treatment.
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  18. Wave Life Sciences reports first therapeutic RNA editing in humans for Alpha-1 Antitrypsin Deficiency, boosting stock by 63%.
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  19. Wave Life Sciences achieves first therapeutic RNA editing in humans with WVE-006 for Alpha-1 Antitrypsin Deficiency in RestorAATion-2 trial.
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  20. Horizon Surgical Systems secures $30M in Series A funding to advance AI-enabled robotic microsurgery for ophthalmic applications.
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  21. Antiverse secures £3.5M to enhance AI-driven antibody design platform targeting GPCRs and ion channels.
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  22. Quest Diagnostics completes acquisition of OhioHealth lab assets to expand cost-effective laboratory services in Ohio.
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  23. The global diabetes drug market is projected to reach $107 billion by 2032, driven by new product approvals and increasing prevalence of Diabetes Mellitus.
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  24. Lundbeck acquires Longboard Pharmaceuticals for $2.6 billion, enhancing its pipeline with bexicaserin for Developmental and Epileptic Encephalopathies.
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  25. NYU Langone appoints Dr. Shridar Ganesan to lead a new Molecular Oncology program, focusing on personalized cancer treatment through advanced molecular diagnostics.
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