January 29, 2025 - 🧬 [nGram] Today’s Pharma Scoop: Atalanta's $97M Series B & Tris Pharma's Positive Study


  1. Atalanta Therapeutics secures $97 million to advance RNAi therapies for CNS diseases
    • Atalanta Therapeutics completed a $97 million Series B financing to support Phase 1 trials for RNAi therapies targeting KCNT1-related epilepsy and Huntington’s disease.
    • The financing was co-led by EQT Life Sciences and Sanofi Ventures, with participation from several other investors.
    • The funds will help progress the therapies towards IND submissions and initiate Phase 1 trials.
    • Atalanta's di-siRNA platform aims to deliver oligonucleotide therapies to the central nervous system.
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  2. Tris Pharma reports positive results for cebranopadol in intranasal abuse potential study
    • Tris Pharma announced positive data from an intranasal human abuse potential study for cebranopadol, showing significantly lower abusability compared to oxycodone.
    • The study involved nondependent recreational opioid users and demonstrated less drug liking for cebranopadol at a supratherapeutic dose.
    • Cebranopadol, a dual-NMR agonist, showed slower absorption intranasally compared to orally, suggesting minimal nasal mucosa absorption.
    • Tris plans to present full results at a medical congress and aims for a New Drug Application submission later this year.
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